Head-Down Tilt Bed Rest Studies as a Terrestrial Analog for Spaceflight Associated Neuro-Ocular Syndrome

Frontiers in Neurology

Heather E. Moss²  Andrew G. Lee⁵  Joshua Ong^1,10 

[1] 0Departments of Ophthalmology, Stanford University, Palo Alto, CA, United States;;1Departments of Neurology &Baylor College of Medicine and the Center for Space Medicine, Houston, TX, United States;Department of Ophthalmology, Houston Methodist Hospital, Houston, TX, United States;Department of Ophthalmology, The University of Iowa Hospitals and Clinics, Iowa City, IA, United States;Department of Ophthalmology, University of Texas Medical Branch, Galveston, TX, United States;Departments of Ophthalmology, Neurology, and Neurosurgery, Weill Cornell Medicine, New York, NY, United States;Texas A and M College of Medicine, Bryan, TX, United States;The Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, United States;University of Pittsburgh School of Medicine, Pittsburgh, PA, United States;University of Texas MD Anderson Cancer Center, Houston, TX, United States;

关键词: spaceflight associated neuro-ocular syndrome;    head-down tilt bed rest;    astronaut;    space medicine;    optic disc edema;    microgravity;   

DOI  :  10.3389/fneur.2021.648958

来源: DOAJ

【 摘 要 】

Astronauts who undergo prolonged periods of spaceflight may develop a unique constellation of neuro-ocular findings termed Spaceflight Associated Neuro-Ocular Syndrome (SANS). SANS is a disorder that is unique to spaceflight and has no terrestrial equivalent. The prevalence of SANS increases with increasing spaceflight duration and although there have been residual, structural, ocular changes noted, no irreversible or permanent visual loss has occurred after SANS, with the longest spaceflight to date being 14 months. These microgravity-induced findings are being actively investigated by the United States' National Aeronautics Space Administration (NASA) and SANS is a potential obstacle to future longer duration, manned, deep space flight missions. The pathophysiology of SANS remains incompletely understood but continues to be a subject of intense study by NASA and others. The study of SANS is of course partially limited by the small sample size of humans undergoing spaceflight. Therefore, identifying a terrestrial experimental model of SANS is imperative to facilitate its study and for testing of preventative measures and treatments. Head-down tilt bed rest (HDTBR) on Earth has emerged as one promising possibility. In this paper, we review the HDTBR as an analog for SANS pathogenesis; the clinical and imaging overlap between SANS and HDTBR studies; and potential SANS countermeasures that have been or could be tested with HDTBR.

【 授权许可】

Unknown