Chemo-selective Synthesis of [indoline-3,4'-isoxazolo[5,4-b]pyridine Fused spirooxindole Derivatives via Brønsted Acid Catalysed Three–Component Tandem Knoevenagel/Michael Addition Reaction

Results in Chemistry

Ram Awatar Maurya¹  Panneerselvam Yuvaraj²  Dhruba Jyoti Boruah³ 

[1] Academy of Scientific and Innovative Research (AcSIR), CSIR-NEIST Campus, India;;CSIR-North East Institute of Science &Applied Organic Chemistry Group, Chemical Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat 785006, India;

关键词: Bronsted acid catalysed;    Chemo-selective;    Tandem reaction;    Spirooxindole;    Eco-friendly;   

DOI  :  

来源: DOAJ

【 摘 要 】

With their exceptional three-dimensional structural topographies, spirooxindoles are known best for privileged chemotypes for diverse biological applications. We report herin a highly convergent and efficient protocol, for the facile chemoselective synthesis of a library of [indoline-3,4′-isoxazolo[5,4-b]pyridine fused spirooxindole derivatives, has been achieved by a Brønsted acid catalyzed three component tandem Knoevenagel/Michael addition. Interestingly, the method not only offers the benefits of operational simplicity, but also chemoselective and atom economic with excellent yields of the targeted molecule. The reaction mechanism and substrate scope of this novel reaction has been thoroughly out lined.

【 授权许可】

Unknown