The Role of Brown Adipose Tissue Dysfunction in the Development of Cardiovascular Disease

Frontiers in Endocrinology

Ping-Jin Gao²  Hong-Jin Chen²  Ting Meng³  Cheng-Chao Ruan³ 

[1] Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai, China;Shanghai Institute of Hypertension, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Bioactive Small Molecules, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai, China;

关键词: brown adipose tissue;    cardiovascular diseases;    obesity;    adipokines;    adipocyte;   

DOI  :  10.3389/fendo.2021.652246

来源: DOAJ

【 摘 要 】

Brown adipose tissue (BAT), consisted of brown adipocytes and stromal vascular fraction, which includes endothelial cells, lymphocytes, fibroblasts and stem cells, plays a vital role in regulating cardiovascular health and diseases. As a thermogenic organ, BAT can influence body through strengthening energy expenditure by promoting glucose and lipid metabolism. In addition, BAT is also an endocrine organ which is able to secret adipokines in an autocrine and/or paracrine fashion. BAT plays a protective role in cardiovascular system through attenuating cardiac remodeling and suppressing inflammatory response. In this review, we summarize the advances from the discovery of BAT to the present and provide an overview on the role of BAT dysfunction in cardiovascular diseases.

【 授权许可】

Unknown