Enhancement of High-Intensity Focused Ultrasound Heating by Short-Pulse Generated Cavitation

Applied Sciences

Shin-ichiro Umemura¹  Ryo Takagi²  Shin Yoshizawa² 

[1] Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, Sendai 980-8579, Japan;Department of Communications Engineering, Graduate School of Engineering, Tohoku University, Sendai 980-8579, Japan;

关键词: HIFU;    focused ultrasound;    cavitation;    microbubble;    ultrasound imaging;   

DOI  :  10.3390/app7030288

来源: DOAJ

【 摘 要 】

A target tissue can be thermally coagulated in high-intensity focused ultrasound (HIFU) treatment noninvasively. HIFU thermal treatments have been clinically applied to various solid tumors. One of the problems in HIFU treatments is a long treatment time. Acoustically driven microbubbles can accelerate the ultrasonic heating, resulting in the significant reduction of the treatment time. In this paper, a method named “trigger HIFU exposure” which employs cavitation microbubbles is introduced and its results are reviewed. A trigger HIFU sequence consists of high-intensity short pulses followed by moderate-intensity long bursts. Cavitation bubbles induced in a multiple focal regions by rapidly scanning the focus of high-intensity pulses enhanced the temperature increase significantly and produced a large coagulation region with high efficiency.

【 授权许可】

Unknown