The ginsenoside metabolite compound K inhibits hormone-independent breast cancer through downregulation of cyclin D1

Journal of Functional Foods

Ji Su Lee¹  Seung Joon Lee²  Eunjung Lee³  Sanguine Byun⁴  Tae-Gyu Lim⁵ 

[1] CELLTRION Inc., Incheon, 22014, Republic of Korea;Department of Agricultural Biotechnology, Seoul National University, Seoul 08826, Republic of Korea;Division of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea;Korea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, Republic of Korea;Traditional Alcoholic Beverage Research Team, Korea Food Research Institute, Wanju-gun, Jeollabuk-do 55365, Republic of Korea;

关键词: Compound K;    Hormone-independent breast cancer;    Cyclin D1;   

DOI  :  

来源: DOAJ

【 摘 要 】

Various types of ginsenosides are present in ginseng and have been recognized for their health-promoting effects. Compound K (CK) is a metabolite of ginsenoside Rb1 and reportedly exerts chemotherapeutic effects against several types of cancers. However, the anti-cancer effect and the molecular mechanism of CK against hormone-independent breast cancer is unknown. Through a direct comparison, it was discovered that CK elicits the strongest anti-cancer effect against breast cancer cells when compared to other ginsenosides. CK treatment suppresses the growth of hormone-independent human breast cancer cells and induces G1 phase cell cycle arrest. CK also markedly suppresses tumor growth in a mouse xenograft model, concomitant with the suppression of cyclin D1 via protein degradation. These findings suggest that CK can be used to target hormone-independent breast cancers by inducing degradation of cyclin D1.

【 授权许可】

Unknown