Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

Cells

YuYoung Jeong¹  Qian Cai¹ 

[1] Department of Cell Biology and Neuroscience, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA;

关键词: mitophagy;    mitophagosome;    lysosome;    mitochondrial dynamics;    mitochondrial quality control;    alzheimer’s disease;    parkinson’s disease;    huntington’s disease;    amyotrophic lateral sclerosis;    aging;   

DOI  :  10.3390/cells9010150

来源: DOAJ

【 摘 要 】

Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease. Mitochondria are the main cellular energy powerhouses, supplying most of ATP by oxidative phosphorylation, which is required to fuel essential neuronal functions. Efficient removal of aged and dysfunctional mitochondria through mitophagy, a cargo-selective autophagy, is crucial for mitochondrial maintenance and neuronal health. Mechanistic studies into mitophagy have highlighted an integrated and elaborate cellular network that can regulate mitochondrial turnover. In this review, we provide an updated overview of the recent discoveries and advancements on the mitophagy pathways and discuss the molecular mechanisms underlying mitophagy defects in Alzheimer’s disease and other age-related neurodegenerative diseases, as well as the therapeutic potential of mitophagy-enhancing strategies to combat these disorders.

【 授权许可】

Unknown