Comprehensive Analysis of Genes Associated With Sudden Infant Death Syndrome

Frontiers in Pediatrics

Ahmed Bamaga²  Syed Adnan Shahzad³  Sahar Hakamy⁴  Husam Malibary⁵  Mursleen Ahmad⁶  Hisham Nasief⁷  Meshari Alaifan⁸  Maher Kurdi⁹  Sidra Khalid^1,10  Riffat Mehboob^1,10  Abeer Mirdad^1,11  Amber Hassan^1,12  Syed Amir Gilani^1,12 

[1] 0Paediatric Department, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia;1Neurology and Pediatric Department, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia;2Faculty of Medicine and University Hospital of Cologne, Institute of Virology, University of Cologne, Cologne, Germany;Center of Excellence in Genomic Research, King Abdulaziz University, Jeddah, Saudi Arabia;Department of Internal Medicine, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia;Department of Medicine, Sahiwal Medical College, Sahiwal, Pakistan;Department of Obstetric and Gynecology, Faculty of Medicine, King Abdulaziz University and Hospital, Jeddah, Saudi Arabia;Department of Paediatrics, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia;Department of Pathology, Faculty of Medicine in Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia;Lahore Medical Research Center, LLP, Lahore, Pakistan;Pediatric Department, East Jeddah Hospital, Jeddah, Saudi Arabia;Research Unit, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan;

关键词: sudden infant death syndrome;    channelopathies;    sodium channels;    cardiac channel genes;    breathing control;    neuropathology;   

DOI  :  10.3389/fped.2021.742225

来源: DOAJ

【 摘 要 】

Background: Sudden infant death syndrome (SIDS) is a tragic incident which remains a mystery even after post-mortem investigation and thorough researches.Methods: This comprehensive review is based on the genes reported in the molecular autopsy studies conducted on SIDS so far. A total of 20 original studies and 7 case reports were identified and included in this analysis. The genes identified in children or adults were not included. Most of the genes reported in these studies belonged to cardiac channel and cardiomyopathy. Cardiac channel genes in SIDS were scrutinized for further analysis.Results: After screening and removing the duplicates, 42 unique genes were extracted. When the location of these genes was assessed, it was observed that most of these belonged to Chromosomes 11, 1 and 3 in sequential manner. The pathway analysis shows that these genes are involved in the regulation of heart rate, action potential, cardiac muscle cell contraction and heart contraction. The protein-protein interaction network was also very big and highly interactive. SCN5A, CAV3, ALG10B, AKAP9 and many more were mainly found in these cases and were regulated by many transcription factors such as MYOG C2C1 and CBX3 HCT11. Micro RNA, “hsa-miR-133a-3p” was found to be prevalent in the targeted genes.Conclusions: Molecular and computational approaches are a step forward toward exploration of these sad demises. It is so far a new arena but seems promising to dig out the genetic cause of SIDS in the years to come.

【 授权许可】

Unknown