Synthetic Glycopolypeptide Micelle for Targeted Drug Delivery to Hepatic Carcinoma

Polymers

Wei Wang¹  Pengqiang Li¹  Jiandong Han¹  Jinjin Chen²  Di Li²  Weiguo Xu² 

[1] Department of Chemistry, Changchun University of Science and Technology, Changchun 130022, China;Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;

关键词: glycopolypeptide;    micelle;    targeting chemotherapy;    controlled drug release;    hepatic carcinoma;   

DOI  :  10.3390/polym10060611

来源: DOAJ

【 摘 要 】

The targeted delivery of chemotherapy drugs to tumor lesions is a major challenge for the treatment of tumors. Up until now, various polymeric nanoparticles have been explored to improve the targetability of these therapeutic drugs through passive or active targeting processes. In the design and construction of polymer nanoparticles, glycopolypeptide has shown great potential owing to its excellent targeting ability and biocompatibility. In order to enhance the antitumor effect of doxorubicin (DOX), a glycopolypeptide-based micelle (GPM) modified by α-lactose (Lac) was synthesized for targeted treatment of hepatoma. The DOX-loaded GPM (i.e., GPM/DOX) could significantly target human hepatoma (HepG2) cells and further inhibit their proliferation in vitro. Additionally, GPM/DOX exhibited a much higher drug accumulation in tumor tissue and a stronger antitumor effect in vivo than free DOX. The above results revealed that this drug delivery system provides a promising platform for the targeting therapy of hepatic cancer.

【 授权许可】

Unknown