Current Trends of Microfluidic Single-Cell Technologies

International Journal of Molecular Sciences

Amogh Kumar¹  TuhinSubhra Santra¹  Pallavi Shinde¹  Koyel Dey¹  Loganathan Mohan¹  Anjali Maddi¹  Fan-Gang Tseng²  Moeto Nagai³  Hwan-You Chang⁴  AlexanderN. Patananan⁵ 

[1] Department of Engineering Design, Indian Institute of Technology Madras, Tamil Nadu 600036, India;Department of Engineering and System Science, National Tsing Hua University, Hsinchu City 30071, Taiwan;Department of Mechanical Engineering, Toyohashi University of Technology, Toyohashi 441-8580, Japan;Department of Medical Science, National Tsing Hua University, Hsinchu City 30071, Taiwan;Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA;

关键词: single-cell;    lab-on-a-chip;    microfluidics Bio-MEMS;    manipulation;    diagnosis;    therapeutics;    drug delivery;   

DOI  :  10.3390/ijms19103143

来源: DOAJ

【 摘 要 】

The investigation of human disease mechanisms is difficult due to the heterogeneity in gene expression and the physiological state of cells in a given population. In comparison to bulk cell measurements, single-cell measurement technologies can provide a better understanding of the interactions among molecules, organelles, cells, and the microenvironment, which can aid in the development of therapeutics and diagnostic tools. In recent years, single-cell technologies have become increasingly robust and accessible, although limitations exist. In this review, we describe the recent advances in single-cell technologies and their applications in single-cell manipulation, diagnosis, and therapeutics development.

【 授权许可】

Unknown