High correlation between human rhinovirus type C and children with asthma exacerbations in Taiwan

Journal of Microbiology, Immunology and Infection

Jiu-Yao Wang¹  Ching-Chung Tsai²  Hong-Ren Yu³  Ting-I. Lin⁴  Ching-Chi Yang⁵  Yen-Ting Lin⁶  Tsun-Mei Lin⁷  Yu-Tsun Su⁸  Shang-Shyue Tsai⁹  Ya-Ling Huang⁹  Yu-Cheng Tsai^1,10  Ming-Chun Yang^1,10 

[1] Asanga International Aid, Kaohsiung, Taiwan;Corresponding author. Department of Pediatrics, College of Medicine, National Cheng Kung University, 1 Ta-Hsueh Road, Tainan 70101, Taiwan. Fax: [phone].;Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan;Love Child Clinic, Hsinchu County, Taiwan;School of Chinese Medicine for Post Baccalaureate, I-Shou University, Kaohsiung, Taiwan;School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan;Department of Healthcare Administration, I-Shou University, Kaohsiung, Taiwan;Division of Pediatric Allergy, Immunology, and Pulmonology, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan;Division of Pediatric Infectious Disease, Department of Pediatrics, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan;The Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan;

关键词: Asthma;    Asthma exacerbation;    Children;    Rhinovirus;    Rhinovirus C;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background/Purposes: Human rhinovirus type C (HRV-C) has been associated with asthma exacerbation (AE) in children in several countries. However, in Taiwan the association between HRV, especially HRV-C, and AE in children has yet to be elucidated. We sought to investigate the prevalence of respiratory viruses in children with acute lower respiratory tract infection (ALRTI) in Taiwan and the association between different types of HRV and AE in children. Methods: This prospective study was conducted from 2011 to 2013, and enrolled children with ALRTI, including an asthma exacerbation group (AE; n = 28) and a Non-asthma group (n = 66). Viruses were detected by culture, reverse transcription-polymerase chain reaction, and molecular sequencing of nasopharyngeal swabs. Results: The prevalence of identified respiratory viruses was 78.6% in the AE group and 65.2% in the Non-asthma group. The prevalence rates of HRV and HRV-C were significantly higher in the AE group than in the Non-asthma group (67.9% vs. 33.3% in HRV, p = 0.002; and 50% vs. 15.2% in HRV-C, p < 0.001). Among the children with HRV, the prevalence of HRV-C (68.4%) was higher than that of the other types of HRV (31.6%, including HRV-A 26.3%, and HRV-B 5.3%) in the AE group but not in the Non-asthma group (40.9% vs. 59.1%). Conclusions: HRV is the most predominant viral infection responsible for pediatric AE in Taiwan, and HRV-C is responsible for more of these exacerbations than HRV-A or HRV-B.

【 授权许可】

Unknown