Effect of Maternal Exercise on Telomere Length and Telomere-Regulating Protein of Offspring in Rat

운동과학

关键词: telomere;    maternal exercise;    skeletal muscle;    cardiac muscle;    aging;   

DOI  :  10.15857/ksep.2017.26.4.267

来源: DOAJ

【 摘 要 】

PURPOSE This study was performed to investigate the effect of maternal exercise on cardiac and skeletal muscle telomere length and telomere repeat binding factor 2 (TRF2) in rat offspring. METHODS Sprague-Dawley rats (10 wk, N=21) were randomly assigned into control (CON), exercise during pregnancy (ExD), and exercise before and during pregnancy (ExBD) groups. Maternal training was performed on a rodent treadmill for 1 hour at 60-75% VO2max for 3 weeks (5 d/w) before and during pregnancy respectively. The offspring were sacrificed at birth and telomere length and TRF2 expression were measured with cardiac and skeletal muscle samples. RESULTS CON group had significantly longer telomere length (p=.011, p=.049) and higher TRF2 expression (p=.011, p=.002) than other two groups in skeletal muscle of offspring. In the cardiac muscle, CON group showed longer telomere length compared with ExD group in offspring (p=.001). CONCLUSIONS Intense maternal exercise before or during pregnancy may negatively affect their new offspring’s cardiac and skeletal muscle telomere length and TRF2 expression.

【 授权许可】

Unknown