Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells

Frontiers in Immunology

Francesco Fazi¹  Alessia Iaiza¹  Claudia Tito¹  Alessandro Fatica²  Silvia Masciarelli³  Enzo Gallo⁴  Mirella Marino⁴  Federico Venuta⁵  Andrea Sacconi⁶  Giulia Fontemaggi⁶  Giovanni Blandino⁶  Federica Ganci⁶  Vincenzo Petrozza⁷  Enrico Melis⁸ 

[1] Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy;Department of Biology and Biotechnology ‘Charles Darwin’, Sapienza University of Rome, Rome, Italy;Department of Life Science and Public Health, Histology and Embryology Unit, Catholic University of the Sacred Hearth, Rome, Italy;Department of Pathology, IRCCS Regina Elena National Cancer Institute, Rome, Italy;Department of Thoracic Surgery, Sapienza University of Rome, Rome, Italy;Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy;Pathology Unit, ICOT, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy;Thoracic Surgery, IRCCS Regina Elena National Cancer Institute, Rome, Italy;

关键词: thymoma;    thymic carcinoma;    thymic epithelial tumors (TETs);    ncRNAs (non coding RNAs);    miRNA - microRNA;    lncRNA - long noncoding RNA;   

DOI  :  10.3389/fimmu.2022.867181

来源: DOAJ

【 摘 要 】

Thymic Epithelial Tumors (TETs) arise from epithelial cells of the thymus and are very rare neoplasms comprising Thymoma, Thymic carcinoma, and Thymic Neuroendocrine tumors that still require in-depth molecular characterization. Long non-coding RNAs (lncRNAs) are emerging as relevant gene expression modulators involved in the deregulation of several networks in almost all types of human cancer, including TETs. LncRNAs act at different control levels in the regulation of gene expression, from transcription to translation, and modulate several pathways relevant to cell fate determination under normal and pathological conditions. The activity of lncRNAs is strongly dependent on their expression, localization, and post-transcriptional modifications. Starting from our recently published studies, this review focuses on the involvement of lncRNAs in the acquisition of malignant traits by neoplastic thymic epithelial cells, and describes the possible use of these molecules as targets for the design of novel therapeutic approaches specific for TET. Furthermore, the involvement of lncRNAs in myasthenia gravis (MG)-related thymoma, which is still under investigation, is discussed.

【 授权许可】

Unknown