Prevalence of Bladder and Bowel Dysfunction in Duchenne Muscular Dystrophy Using the Childhood Bladder and Bowel Dysfunction Questionnaire

Life

Bregje Jaeger¹  Evita G. Medici-van den Herik²  Catharina G. Faber³  Judith M. Lionarons³  Sylvia Klinkenberg³  Johanna M. Fock⁴  Inge Cuppen⁵  Anita C. E. Vreugdenhil⁶  Imelda J. M. de Groot⁷  Frans J. M. Feron⁸  Desiree M. J. Vrijens⁹  Erik H. Niks^1,10  Jos G. M. Hendriksen^1,10  Johan S. H. Vles^1,11  Rinske Hoogerhuis^1,12  Nicky Platte-van Attekum^1,12 

[1]Department of Neurology, Amsterdam University Medical Center, 1105 AZ Amsterdam, The Netherlands

[2]Department of Neurology, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands

[3]Department of Neurology, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands

[4]Department of Neurology, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands

[5]Department of Neurology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands

[6]Department of Pediatrics, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands

[7]Department of Rehabilitation Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

[8]Department of Social Medicine, Maastricht University, 6229 ER Maastricht, The Netherlands

[9]Department of Urology, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands

[10]Duchenne Center Netherlands, 2333 ZA Leiden, The Netherlands

[11]School for Mental Health and Neuroscience, Maastricht University, 6229 ER Maastricht, The Netherlands

[12]Youth Healthcare Center South Limburg, 6411 TE Heerlen, The Netherlands

关键词: Duchenne muscular dystrophy;    bladder and bowel dysfunction;    lower urinary tract symptoms;    urinary incontinence;    constipation;   

DOI  :  10.3390/life11080772

来源: DOAJ

【 摘 要 】

Introduction: Lower urinary tract symptoms (LUTS) and gastrointestinal (GI) problems are common in Duchenne muscular dystrophy (DMD), but not systematically assessed in regular care. We aimed to determine the prevalence of bladder and bowel dysfunction (BBD) in DMD patients compared with healthy controls (HC). Methods: The Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) based on the International Rome III criteria and the International Children’s Continence Society was filled out by 57 DMD patients and 56 HC. Additionally, possible associations of BBD with, for example, medication use or quality of life were evaluated in an additional questionnaire developed by experts. Results: In 74% of patients versus 56% of HC ≥ 1 LUTS (n.s.) were reported, 68% of patients versus 39% of HC reported ≥1 bowel symptom (p = 0.002) and 53% of patients versus 30% of HC reported combined LUTS and bowel symptoms (p = 0.019). A negative impact of BBD on daily life functioning was reported by 42% of patients. Conclusions: These data underscore that standard screening for BBD is needed and that the CBBDQ could be of added value to optimize DMD care.

【 授权许可】

Unknown