Association of the Metabolic Score Using Baseline FDG-PET/CT and dNLR with Immunotherapy Outcomes in Advanced NSCLC Patients Treated with First-Line Pembrolizumab

Cancers

Laura Mezquita¹  Marie-Ange Massiani²  Boris Duchemann³  Gérald Bonardel⁴  Laurence Champion⁵  Romain-David Seban⁵  Margot Playe⁶  Michael Soussan⁶  Lucas Goldfarb⁶  Jean-Baptiste Assié⁷  Christos Chouaid⁷  Etienne Giroux-Leprieur⁸  Nicolas Girard⁹ 

[1] Department of Medical Oncology, Hospital Clínic, Laboratory of Translational Genomics and Target Therapeutics in Solid Tumors, IDIBAPS, 08036 Barcelona, Spain;Department of Medical Oncology, Institut Curie, 92210 Saint-Cloud, France;Department of Medical Oncology, Paris 13 University, APHP, Hôpital Avicenne, 93000 Bobigny, France;Department of Nuclear Medicine, Centre Cardiologique du Nord, 93200 Saint-Denis, France;Department of Nuclear Medicine, Institut Curie, 92210 Saint-Cloud, France;Department of Nuclear Medicine, Paris 13 University, APHP, Hôpital Avicenne, 93000 Bobigny, France;Department of Pneumology, Paris-Est University, Centre Hospitalier Inter-Communal de Créteil, Inserm U955, UPEC, IMRB, équipe CEpiA, 94010 Créteil, France;Department of Respiratory Diseases and Thoracic Oncology, APHP, Hôpital Ambroise Paré, 92100 Boulogne-Billancourt, France;Institut du Thorax Curie Montsouris, Institut Curie, F-75006 Paris, France;

关键词: FDG-PET;    NSCLC;    first-line immunotherapy;    derived neutrophils to lymphocytes ratio;    total metabolic tumor volume;    prognosis;   

DOI  :  10.3390/cancers12082234

来源: DOAJ

【 摘 要 】

Background: We aimed to assess the clinical utility of a previously published score combining the total metabolic tumor volume (TMTV) on baseline FDG-PET/CT and pretreatment derived from the neutrophils to lymphocytes ratio (dNLR) for prognostication in NSCLC patients undergoing first-line immunotherapy (IT). Methods: In this multicenter retrospective study, 63 advanced NSCLC patients with a PD-L1 tumor proportion score (TPS) ≥50%, who underwent FDG-PET/CT before first-line IT, treated from January 2017 to September 2019, were enrolled. Associations between this score and the progression-free survival (PFS), overall survival (OS), disease control rate (DCR), and overall response rate (ORR) were evaluated. Results: The median (m) PFS and mOS were 7.7 (95% CI 4.9–10.6) and 12.1 (8.6–15.6) months, respectively, and DCR and ORR were 65% and 58%, respectively. mOS was 17.9 months (14.6 not reached) for the good group versus 13.8 (95%CI 8.4–18.9) and 6.6 (CI 2.0–11.2) months for the intermediate and poor groups, respectively. mPFS was 15.1 (95%CI 12.1–20.0) months for the good group versus 5.2 (1.9–8.5) and 1.9 (95%CI 1.3–2.5) months for the intermediate and poor groups, respectively. The poor prognosis group was associated with DCR and ORR (p < 0.05). Conclusions: The metabolic score combining TMTV on the baseline FDG-PET/CT scan and pretreatment dNLR was associated with the survival and response in a cohort of advanced NSCLC patients with ≥50% PD-L1 receiving frontline IT.

【 授权许可】

Unknown