The potential of excipients to improve the efficiency of immuno-oncology therapy.

Journal of Excipients and Food Chemicals

Shireesh Apte¹ 

[1] Editorial Board, Journal of Excipients and Food Chemicals;

关键词: Cell culture media;    immuno-oncology;    CAR-T cells;    functional excipient;    chimeric antigen receptor;   

DOI  :  

来源: DOAJ

【 摘 要 】

The cocktail of substances used in cell culture media to cryopreserve, transfect, grow, expand, fractionate, concentrate, wash and remove impurities from leukapheresis harvested T-cells are functional excipients. Even though most of them are not present in the final product, they nonetheless have the potential – during in vitro manufacture - to determine the subsequent in vivo proliferative capacity, persistance, safety and compositional phenotype of the injected re-engineered T-cells. Thus, while the chimeric antigen receptor and co-stimulatory signaling molecules are necessary for CAR-T cell functionality, they may not be sufficient to achieve this functionality unless manufactured using the right cocktail of functional excipients.

【 授权许可】

Unknown