Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections

Frontiers in Pediatrics

Tejas P. Joshi¹  Sara Anvari²  Meera R. Gupta²  Carla M. Davis³  Joud Hajjar³ 

[1] Baylor College of Medicine, Houston, TX, United States;Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States;Wiliam T Shearer Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, United States;

关键词: hyper-IgE syndrome;    dupilumab;    severe eczema;    primary immunodeficencies;    pediatrics-children;   

DOI  :  10.3389/fped.2021.646997

来源: DOAJ

【 摘 要 】

The efficacy of dupilumab in pediatric patients with severe eczema presenting in the setting of elevated immunoglobulin E (IgE) levels and recurrent bacterial skin infections is not well-understood. Here we present the case of a child with elevated IgE levels in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with molecularly proven cases of hyper IgE (HIGE) syndrome. Our case supports the notion that dupilumab may have a seminal application in treating severe eczema that occurs in the setting of elevated IgE levels and recurrent bacterial skin infections.

【 授权许可】

Unknown