National Antimicrobial Consumption: Analysis of Central Warehouses Supplies to In-Patient Care Health Facilities from 2017 to 2019 in Uganda

Tropical Medicine and Infectious Disease

Alexandre Delamou¹  Kudakwashe Takarinda²  Pruthu Thekkur²  Stella Maris Nanyonga³  Juliet Sanyu Namugambe⁴  Monica Imi⁵  Harriet Akello⁶  Francis Moses⁷  Zikan Koroma⁷  Engy Ali⁸  Veerle Hermans⁸  Freddy Eric Kitutu⁹  Joseph Ngobi Mwoga^1,10 

[1] Africa Centre of Excellence for Prevention and Control of Transmissible Diseases (CEA-PCMT), University Gamal Abdel Nasser, Conakry, PB: 4099 Maferinyah, Guinea;Centre for Operational Research, International Union Against Tuberculosis and Lung Disease, 75006 Paris, France;Clinical Epidemiology Unit, College of Health Sciences, Makerere University, P.O. Box 7072 Kampala, Uganda;Department of Pharmacy, Mbarara University of Science and Technology, Mbarara, P.O. Box 1410 Mbarara, Uganda;Enabel, The Belgian Development Agency, P.O. Box 40131 Kampala, Uganda;Ministry of Health Uganda, P.O. Box 7272 Kampala, Uganda;Ministry of Health and Sanitation, 00232 Freetown, Sierra Leone;Médecins Sans Frontières–Operational Centre Brussels, Medical Department, Operational Research Unit (LuxOR), Luxembourg De Manstraat 6, 2100 Deurne, Brussels, Belgium;Sustainable Pharmaceutical Systems (SPS) Unit, Pharmacy Department, School of Health Sciences, Makerere University, P.O. Box 7072, Kampala, Uganda;World Health Organisation County Office, P.O. Box 24578 Kampala, Uganda;

关键词: antimicrobial resistance;    antimicrobial consumption;    antimicrobial stewardship;    Uganda;    health facilities;    antimicrobials;   

DOI  :  10.3390/tropicalmed6020083

来源: DOAJ

【 摘 要 】

Antimicrobial consumption (AMC) surveillance at global and national levels is necessary to inform relevant interventions and policies. This study analyzed central warehouse antimicrobial supplies to health facilities providing inpatient care in Uganda. We collected data on antimicrobials supplied by National Medical Stores (NMS) and Joint Medical Stores (JMS) to 442 health facilities from 2017 to 2019. Data were analyzed using the World Health Organization methodology for AMC surveillance. Total quantity of antimicrobials in defined daily dose (DDD) were determined, classified into Access, Watch, Reserve (AWaRe) and AMC density was calculated. There was an increase in total DDDs distributed by NMS in 2019 by 4,166,572 DDD. In 2019, Amoxicillin (27%), Cotrimoxazole (20%), and Metronidazole (12%) were the most supplied antimicrobials by NMS while Doxycycline (10%), Amoxicillin (19%), and Metronidazole (10%) were the most supplied by JMS. The majority of antimicrobials supplied by NMS (81%) and JMS (66%) were from the Access category. Increasing antimicrobial consumption density (DDD per 100 patient days) was observed from national referral to lower-level health facilities. Except for NMS in 2019, total antimicrobials supplied by NMS and JMS remained the same from 2017 to 2019. This serves as a baseline for future assessments and monitoring of stewardship interventions.

【 授权许可】

Unknown