Multi-center Clinical Study of Nimotuzumab Combined with PF Regimen in Induction Treatment of Locally Advanced Nasopharyngeal Carcinoma

Zhongliu Fangzhi Yanjiu

NING Xuejian¹  HUANG Haixin²  LU Ying²  CHEN Dagui²  LUO Zhanxiong³  LIU Meilian⁴  WANG Rensheng⁵  LIU Wenqi⁶  HUANG Changjie⁷  GAO Jianquan⁸  LIANG Jinhui⁸ 

[1] Oncology Department, Liuzhou Traditional Chinese Medical Hospital, Liuzhou 545001, China;Oncology Department, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005, China;Radiotherapy Department, Liuzhou People's Hospital, Liuzhou 545001, China;Radiotherapy Department, The Affiliated Hospital of Guilin Medical University, Guilin 541001, China;Radiotherapy Department, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China;Radiotherapy Department, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530037, China;Radiotherapy Department, The Second Nanning People's Hospital, Nanning 530031, China;Radiotherapy Department, Wuzhou Red Cross Hospital, Wuzhou 546002, China;

关键词: nasopharyngeal carcinoma;    egfr monoclonal antibody;    induction treatment;    efficacy;    adverse reaction;   

DOI  :  10.3971/j.issn.1000-8578.2019.18.2031

来源: DOAJ

【 摘 要 】

Objective To investigate the safety and efficacy of the induction therapy of nimotuzumab combined with PF regimen (cisplatin+5-fluorouracil) in the follow-up treatment of locally advanced nasopharyngeal carcinoma patients received concurrent chemoradiotherapy. Methods We included 118 patients with stage Ⅲ-Ⅳa nasopharyngeal carcinoma, 58 cases in NPF group (induction therapy of nimotuzumab combined with PF regimen) and 60 cases in TPF group (induction chemotherapy of docetaxel, cisplatin and fluorouracil regimen). After two cycles of induction therapy, all patients received concurrent cisplatin and intensity-modulated radiotherapy (IMRT), and the safety and short-term efficacy of the two groups were compared. Results Compared with TPF group, NPF induction therapy was more effective for cervical lymph nodes (P=0.036); however, there was no significant difference in the effect of induction therapy on primary lesions, overall effect or the immediate effect of the whole course of treatment(P > 0.05). Compared with TPF group, neutropenia and gastrointestinal reaction in the NPF group was significantly improved during the induction therapy (P=0.028, P=0.049); gastrointestinal reaction, oral mucositis and radiation dermatitis in the NPF group were significantly improved during the concurrent chemoradiotherapy (P=0.038, P=0.041, P=0.035). Conclusion For locally advanced nasopharyngeal carcinoma patients received cisplatin concurrent IMRT, the induction therapy of nimotuzumab combined with PF regimen have a better lymph node remission rate and mild adverse reactions. Patients had better tolerance in subsequent concurrent chemoradiotherapy, but the long-term efficacy requires further follow-up observation.

【 授权许可】

Unknown