Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

BMC Complementary Medicine and Therapies

Elena Azzini¹  Hafiz Ansar Rasul Suleria²  Prabhakar Semwal³  Sakshi Painuli³  Alfred Maroyi⁴  William N. Setzer⁵  Ahmet Beyatli⁶  Miquel Martorell⁷  Oksana Sytar⁸  Gulnaz Seitimova⁹  Balakyz Yeskaliyeva⁹  Natália Martins^1,10  Bahare Salehi^1,11  Yasaman Taheri^1,12  Anuj Kumar^1,13  Javad Sharifi-Rad^1,14 

[1]CREA-Research Centre for Food and Nutrition

[2]Department of Agriculture and Food Systems, The University of Melbourne

[3]Department of Biotechnology, Graphic Era University

[4]Department of Botany, University of Fort Hare

[5]Department of Chemistry, University of Alabama in Huntsville

[6]Department of Medicinal and Aromatic Plants, University of Health Sciences

[7]Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción

[8]Department of Plant Biology Department, Taras Shevchenko National University of Kyiv, Institute of Biology

[9]Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University

[10]Faculty of Medicine, University of Porto

[11]Noncommunicable Diseases Research Center, Bam University of Medical Sciences

[12]Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences

[13]Uttarakhand Council for Biotechnology

[14]Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences

关键词: Myricetin;    Antimicrobial;    Antioxidant;    Neuroprotection;    Diabetes;    Cancer;   

DOI  :  10.1186/s12906-020-03033-z

来源: DOAJ

【 摘 要 】

Abstract Several flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical activities on Alzheimer, Parkinson, and Huntington diseases, and even in amyotrophic lateral sclerosis. Also, myricetin has revealed other biological activities, among them as antidiabetic, anticancer, immunomodulatory, cardiovascular, analgesic and antihypertensive. However, few clinical trials have been performed using myricetin as nutraceutical. Thus, this review provides new insights on myricetin preclinical pharmacological activities, and role in selected clinical trials.

【 授权许可】

Unknown