Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction

Reproductive Biology and Endocrinology

Kai-Lun Hu¹  Zimiao Chen²  Enci Cai³  Wenhai Deng⁴  Yi Chen⁵  Congying Wang⁵  Haiyan Yang⁵  Liangshan Mu⁶  Xiaoxue Li⁶  Liping Ju⁶ 

[1] Center for Reproductive Medicine, Peking University Third Hospital;Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University;Department of Nutrition and Food Science, College of Food, Agricultural and Natural Resource Sciences, University of Minnesota;Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University;Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical University;Zhejiang MedicalTech Therapeutics Company;

关键词: Kisspeptin;    KISS1R;    Hypothalamus;    Hypothalamic-pituitary-ovarian axis;    Female reproduction;   

DOI  :  10.1186/s12958-022-00953-y

来源: DOAJ

【 摘 要 】

Abstract Background Kisspeptin is the leading upstream regulator of pulsatile and surge Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as the key governor of the hypothalamic-pituitary-ovary axis. Main text Exogenous kisspeptin or its receptor agonist can stimulate GnRH release and subsequent physiological gonadotropin secretion in humans. Based on the role of kisspeptin in the hypothalamus, a broad application of kisspeptin and its receptor agonist has been recently uncovered in humans, including central control of ovulation, oocyte maturation (particularly in women at a high risk of ovarian hyperstimulation syndrome), test for GnRH neuronal function, and gatekeepers of puberty onset. In addition, the kisspeptin analogs, such as TAK-448, showed promising agonistic activity in healthy women as well as in women with hypothalamic amenorrhoea or polycystic ovary syndrome. Conclusion More clinical trials should focus on the therapeutic effect of kisspeptin, its receptor agonist and antagonist in women with reproductive disorders, such as hypothalamic amenorrhoea, polycystic ovary syndrome, and endometriosis.

【 授权许可】

Unknown