(E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one

Molbank

Nicholas Bailey¹  BradleyO. Ashburn¹  Alaina Atanes¹ 

[1] Ashburn Group, Mathematics, Natural, and Health Sciences Division, University of Hawai‘i West O‘ahu, 91-1001 Farrington Hwy, Kapolei, HI 96707, USA;

关键词: chalcone;    synthesis;    aldol;    leishmaniasis;    neglected tropical disease;   

DOI  :  10.3390/M1184

来源: DOAJ

【 摘 要 】

Natural products known as chalcones show promise as chemotherapeutic agents for the neglected tropical disease known as leishmaniasis. Our objective is to synthesize new targets of opportunity that may lead to better treatments of this debilitating disease. Claisen-Schmidt condensation of 4-chlorobenzaldehyde with 2′-fluoro-4′-methoxyacetophenone using aqueous sodium hydroxide in ethanol yielded the novel compound (E)-3-(4-chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one. The product was obtained in good yield and purity after recrystallization from ethyl acetate/hexane. With the known antiparasitic properties of halogenated chalcones, this novel compound is suitable for antileishmanial activity study.

【 授权许可】

Unknown