Alkylating Agent-Induced Toxicity and Melatonin-Based Therapies

Frontiers in Pharmacology

Alejandro Romero¹  Javier Egea⁴  Francisco López-Muñoz⁵  Oscar Fernández-Capetillo⁶  Russel J. Reiter⁷ 

[1]Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Complutense University of Madrid, Madrid, Spain

[2]Faculty of Health, University Camilo José Cela, Madrid, Spain

[3]Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain

[4]Molecular Neuroinflammation and Neuronal Plasticity Research Laboratory, Research Unit, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria-Hospital Universitario de La Princesa, Madrid, Spain

[5]Neuropsychopharmacology Unit, Hospital Doce de Octubre Research Institute (i+12), Madrid, Spain

[6]Science for Life Laboratory, Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

[7]UTexas Health San Antonio, Long School of Medicine, San Antonio, TX, United States

关键词: melatonin;    alkylating agents;    toxicity;    inflammation;    oxidative stress;    molecular therapeutics;   

DOI  :  10.3389/fphar.2022.873197

来源: DOAJ

【 授权许可】

Unknown