First-Trimester Screening for Gestational Diabetes Mellitus in Twin Pregnancies

Journal of Clinical Medicine

Antonia Varthaliti¹  Argyro Syngelaki¹  Tania Elger¹  Olga Buerger¹  Kypros H. Nicolaides¹  Alan Wright² 

[1] Fetal Medicine Research Institute, King’s College Hospital, London SE5 8BB, UK;Institute of Health Research, University of Exeter, Exeter EX4 4QG, UK;

关键词: first trimester screening;    pyramid of prenatal care;    gestational diabetes mellitus;    twin pregnancies;   

DOI  :  10.3390/jcm10173814

来源: DOAJ

【 摘 要 】

We previously reported a logistic regression model for prediction of GDM from maternal characteristics and medical history in 75,161 singleton pregnancies. In this study of 1376 twin and 13,760 singleton pregnancies recruited at 11–13 weeks’ gestation, we extend the model to include terms for twin pregnancies. We found the respective odds of GDM in dichorionic and monochorionic twin pregnancies to be 1.36 (95% CI: 1.02–1.81) and 2.78 (95% CI: 1.72–4.48) times higher than in singleton pregnancies. In both singleton and twin pregnancies, the risk for GDM increased with maternal age and weight and birth weight z-score of a baby in a previous pregnancy and is higher in women with a previous pregnancy complicated by GDM; in those with a first- or second-degree relative with diabetes mellitus; in women of Black, East Asian, and South Asian racial origin; and in pregnancies conceived through the use of ovulation-induction drugs. In singleton pregnancies, at 10% and 20% false-positive rate, the detection rate was 43% and 58%, respectively. In twin pregnancies, using risk cut-offs corresponding to 10% and 20% false-positive rates in singletons, the respective false-positive rates were 27% and 47%, and the detection rates were 63% and 81%.

【 授权许可】

Unknown