Systematic analysis of overall survival and interactions between tumor mutations and drug treatment

Journal of Hematology & Oncology

Jens Nielsen¹  Francesco Gatto¹ 

[1] Department of Biology and Biological Engineering, Chalmers University of Technology;

关键词: Cancer genomics;    Exceptional response;    Large-scale data analysis;    Systems biology;    Lower-grade glioma;   

DOI  :  10.1186/s13045-016-0249-2

来源: DOAJ

【 摘 要 】

Abstract Background Few exceptional responses in cancer treatment were attributed to a genetic predisposition of the tumor. Methods We analyzed a cohort of 3105 patients from 12 different cancer types and systematically sought the existence of a correlation between overall survival and the interaction of 21 antineoplastic treatments with 6 tumor mutations. Results We identified a single significant correlation resulting in increased overall survival from temozolomide in lower-grade glioma with IDH1 R132H mutations. The trend could not be attributed to either the treatment or the mutation alone. Univariate and multivariate Cox regression demonstrated that this interaction stood as an independent prognostic predictor of survival. Conclusion Our results suggest infrequent instances of exceptional responses ascribable to tumor genomics yet corroborate the existence of an interaction of temozolomide with IDH1 mutations in lower-grade glioma.

【 授权许可】

Unknown