Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment

Frontiers in Pediatrics

Madeleine W. Cunningham¹  Joseph W. May²  Jeremy C. McMurray³  Olcay Y. Jones⁵ 

[1]Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States

[2]Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States

[3]Department of Pediatrics, Walter Reed National Military Medical Center (WRNMMC), Bethesda, MD, United States

[4]Division of Pediatric Cardiology, Walter Reed National Military Medical Center (WRNMMC), Bethesda, MD, United States

[5]Division of Pediatric Rheumatology, WRNMMC, Bethesda, MD, United States

关键词: MIS-C;    myocarditis;    vasculitis;    coronary artery aneurysm;    IL-1 (interleukin-1);   

DOI  :  10.3389/fped.2020.626182

来源: DOAJ

【 摘 要 】

MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.

【 授权许可】

Unknown