Sequential Au(I)-catalyzed reaction of water with o-acetylenyl-substituted phenyldiazoacetates

Beilstein Journal of Organic Chemistry

Yizhou Liu¹  Lei Zhou¹  Yan Zhang¹  Jianbo Wang¹ 

[1] Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China;

关键词: alkyne;    carbene O–H insertion;    cyclization;    diazo compounds;    gold catalysis;    1H-isochromene;   

DOI  :  10.3762/bjoc.7.74

来源: DOAJ

【 摘 要 】

The gold(I)-catalyzed reaction of water with o-acetylenyl-substituted phenyldiazoacetates provides 1H-isochromene derivatives in good yields. The reaction follows a catalytic sequence of gold carbene formation/water O–H insertion/alcohol-alkyne cyclization. The gold(I) complex is the only catalyst in each of these steps.

【 授权许可】

Unknown