The use of quetiapine in treatment of acute psychotic symptoms in an adolescent patient with primary brain calcification: a case report

BMC Psychiatry

Tristan Rigler¹  Maja Drobnič Radobuljac¹  Barbara Plemeniti Tololeski¹  Mirjana Perkovič Benedik²  Katarina Šurlan Popovič³  Primož Kotnik⁴  Marinos Kyriakopoulos⁵  Maruša Debeljak⁶ 

[1] Centre for Mental Health, Unit for Adolescent Psychiatry, University Psychiatric Hospital Ljubljana;Department of Pediatric Neurology, University Medical Centre Ljubljana, University Children’s Hospital;Institute of Radiology, University Medical Centre Ljubljana;Medical Faculty, Chair of Pediatrics, University of Ljubljana;South London and Maudsley NHS Foundation Trust, National and Specialist Inpatient Children’s Unit (Acorn Lodge), Tyson East Two, Bethlem Royal Hospital;Unit for Special Laboratory Diagnostics, University Medical Centre Ljubljana, University Children’s Hospital;

关键词: Primary brain calcification;    Acute psychosis;    Adolescent;    Quetiapine;   

DOI  :  10.1186/s12888-019-2047-1

来源: DOAJ

【 摘 要 】

Abstract Background Primary brain calcification (PBC), a neurodegenerative disorder with characteristic calcium deposits in the basal ganglia and other brain areas, typically presents with various neurological and psychiatric symptoms in the fourth or fifth decade of life or later. We present the case of a patient with psychiatric manifestations much earlier than usual, in the second decade of life. Case presentation The case of an adolescent female with acute psychotic symptoms, emotional instability, disorganized and suicidal behavior, stereotypical movements, below average intelligence and a three-year history of headaches is reported. Among others, the presentation included tactile hallucinations with secondary hypochondriacal delusions, which are rarely described in this diagnosis. Massive calcinations in the area of the basal ganglia and thalamus were determined by computerized tomography. Other causes of brain calcification were excluded. No causative mutations were found in selected genes. All the symptoms apart from lower intellectual abilities improved with quetiapine and sertraline. The patient showed no side effects. Conclusions This case report highlights the successful use of quetiapine for symptomatic treatment of acute psychosis due to PBC in an adolescent without exacerbating extrapyramidal symptoms.

【 授权许可】

Unknown