Infant behavioral reactivity predicts change in amygdala volume 12 years later

Developmental Cognitive Neuroscience

Dominique Phillips¹  Jessica F. Sachs²  Daniel S. Pine³  Ellen Leibenluft⁴  Andrea L. Gold⁴  Anderson Winkler⁴  Courtney A. Filippi⁴  Nathan A. Fox⁵ 

[1] Corresponding author at: 9000 Rockville Pike, Bethesda, MD, 20892, United States.;Department of Human Development and Quantitative Methodology, University of Maryland, College Park, MD, 20742, United States;Department of Psychiatry and Human Behavior, Brown University Warren Alpert Medical School, Providence, RI, 02912, United States;Section on Development and Affective Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892, United States;Section on Mood Dysregulation and Neuroscience, National Institute of Mental Health, Bethesda, MD, 20892, United States;

关键词: Amygdala;    Temperament;    Reactivity;    Brain;    Development;   

DOI  :  

来源: DOAJ

【 摘 要 】

The current study examined the link between temperamental reactivity in infancy and amygdala development in middle childhood. A sample (n = 291) of four-month-old infants was assessed for infant temperament, and two groups were identified: those exhibiting negative reactivity (n = 116) and those exhibiting positive reactivity (n = 106). At 10 and 12 years of age structural imaging was completed on a subset of these participants (n = 75). Results indicate that, between 10 and 12 years of age, left amygdala volume increased more slowly in those with negative compared to positive reactive temperament. These results provide novel evidence linking early temperament to distinct patterns of brain development over middle childhood.

【 授权许可】

Unknown