Genetic Evidence Supporting a Causal Role of Snoring in Erectile Dysfunction

Frontiers in Endocrinology

Changjing Wu¹  Feng Qin¹  Yangchang Zhang²  Wei Wang³  Jiuhong Yuan³  Yang Xiong³  Xin Zhong³  Fuxun Zhang³ 

[1] Andrology Laboratory, West China Hospital, Sichuan University, Chengdu, China;Department of Epidemiology and Health Statistics, School of Public Health and Management, Chongqing Medical University, Chongqing, China;Department of Urology, West China Hospital, Sichuan University, Chengdu, China;

关键词: snoring;    erectile dysfunction;    causal estimates;    Mendelian randomization;    genetic evidence;   

DOI  :  10.3389/fendo.2022.896369

来源: DOAJ

【 摘 要 】

BackgroundThe association between snoring and erectile dysfunction (ED) is inconsistent in multiple observational studies. To clarify the causal association of snoring on ED, we performed this two-sample Mendelian randomization study.Materials and MethodsThe single nucleotide polymorphisms (SNPs) associated with snoring were retrieved from the UK biobank cohort with 314,449 participants (117,812 cases and 196,637 controls). The summary statistics of ED were obtained from the European ancestry with 223,805 subjects (6,175 cases and 217,630 controls). Single-variable Mendelian randomization (MR) and multivariable MR were used to assess the causal relationship between snoring and ED.ResultsSnoring increases the risk of ED (Odds ratio [OR] = 3.45, 95% confidence interval [CI] = 1.68 - 7.09, P < 0.001) in the inverse variance weighting estimator. In sensitivity analyses, the ORs for the weighted median, MR robust adjusted profile score, and MR Pleiotropy Residual Sum and Outlier approach, MR-Egger, and maximum likelihood method are 5.70 (95% CI = 1.19 - 27.21, P < 0.05), 3.14 (95% CI = 1.01 - 9.72, P < 0.05), 3.11 (95% CI = 1.63 - 5.91, P < 0.01), 1.23 (95% CI = 0.01 – 679.73, P > 0.05), and 3.59 (95% CI = 1.07 – 12.00, P < 0.05), respectively. No heterogeneity and pleiotropy are observed (P for MR-Egger intercept = 0.748; P for global test = 0.997; P for Cochran’s Q statistics > 0.05). After adjusting for total cholesterol, triglyceride, low-density lipoprotein, and cigarette consumption, the ORs for ED are 5.75 (95% CI = 1.80 - 18.34, P < 0.01), 4.16 (95% CI = 1.10 - 15.81, P < 0.05), 5.50 (95% CI = 1.62 - 18.69, P < 0.01), and 2.74 (95% CI = 1.06 - 7.10, P < 0.05), respectively.ConclusionThis study provides genetic evidence supporting the causal role of snoring in ED.

【 授权许可】

Unknown