Effects of Quinine, Quinidine and Chloroquine on Human Muscle Nicotinic Acetylcholine Receptors

Frontiers in Pharmacology

Hanns Hatt¹  Brigitte Welbers-Joop²  Desiree Alisch³  Günter Gisselmann³ 

[1] Co. KG, Koeln, Germany;;Cassella-med GmbH &Department of Cell Physiology, Ruhr-University-Bochum, Bochum, Germany;

关键词: quinine;    nocturnal leg cramps;    nicotinic acetylcholine receptor;    two-electrode voltage clamp;    ion channel block;   

DOI  :  10.3389/fphar.2018.01339

来源: DOAJ

【 摘 要 】

The genus Cinchona is known for a range of alkaloids, such as quinine, quinidine, cinchonine, and cinchonidine. Cinchona bark has been used as an antimalarial agent for more than 400 years. Quinine was first isolated in 1820 and is still acknowledged in the therapy of chloroquine-resistant falciparum malaria; in lower dosage quinine has been used as treatment for leg cramps since the 1940s. Here we report the effects of the quinoline derivatives quinine, quinidine, and chloroquine on human adult and fetal muscle nicotinic acetylcholine receptors (nAChRs). It could be demonstrated that the compounds blocked acetylcholine (ACh)-evoked responses in Xenopus laevis oocytes expressing the adult nAChR composed of αβ

【 授权许可】

Unknown