СLINICAL EFFICIENCY OF STATINS IN RHEUMATOID ARTHRITIS: A PILOT STUDY

Medicinskaâ Immunologiâ

V. A. Kozlov¹  N. Yu. Solovieva¹  V. S. Shirinsky¹  I. V. Shirinsky¹  O. I. Zheltova¹ 

[1] ГУ НИИ клинической иммунологии СО РАМН, г. Новосибирск;

关键词: rheumatoid arthritis;    simvastatin;    statins;    treatment;   

DOI  :  10.15789/1563-0625-2007-4-5-505-508

来源: DOAJ

【 摘 要 】

Abstract. Statins are widely used to lower lipid levels and prevent cardiovascular disease. Recently described anti-inflammatory and immunomodulating properties of statins substantiate their application as a potentially novel treatment for autoimmune diseases. We evaluated efficacy and safety of simvastatin (40 mg daily) in patients with active rheumatoid arthritis (RA), as a supplement to stable doses of disease-modifying antirheumatic drugs. After 12 weeks of treatment, there was registered a significant decrease in disease activity score (by 0.89 points), improvement of life quality, and attenuation of pain levels. To confirm efficacy and safety of simvastatin in active RA, a large-scale controlled randomized study should be performed.

【 授权许可】

Unknown