Plasma volume variation across the menstrual cycle among healthy women of reproductive age: A prospective cohort study

Physiological Reports

Hilary J. Bethancourt¹  Asher Y. Rosinger¹  Leigh A. Taylor²  Alison D. Gernand²  Sixtus Aguree² 

[1] Department of Biobehavioral Health The Pennsylvania State University University Park PA USA;Department of Nutritional Sciences The Pennsylvania State University University Park PA USA;

关键词: blood volume;    indocyanine green;    menstruating women;    ovarian cycle;    plasma volume;   

DOI  :  10.14814/phy2.14418

来源: DOAJ

【 摘 要 】

Abstract Increases in reproductive hormones like estrogen, play an important role in the remarkable increases in plasma volume observed in pregnancy. Accurate estimates of plasma volume expansion during pregnancy depend on correctly timing and measuring plasma volume in nonpregnant women. However, to date, there is no consensus on the pattern of plasma volume across the menstrual cycle. We prospectively measured plasma volume in 45 women across a single menstrual cycle. A urine‐based fertility monitor was used to time three clinic visits to distinct points in the menstrual cycle: the early follicular phase (~day 2), periovulation (~day 12), and the mid‐point of the luteal phase (~day 21)—based on a 28‐day cycle length. Healthy women aged 18–41 years with regular menstrual cycles and a healthy body weight were enrolled in the study. At each visit, blood samples were collected before and after injection of 0.25 mg/kg body weight of indocyanine green dye (ICG). Pre‐ and post‐ICG injection plasma samples were used to measure plasma volume. Preinjection samples were used to measure ovarian hormones and plasma osmolality. Mean plasma volume was highest during the early follicular phase (2,276 ± 478 ml); it declined to 2,232 ± 509 ml by the late follicular phase and to 2,228 ± 502 ml by the midluteal phase. This study found that overall variations in plasma volume are small across the menstrual cycle. Therefore, in clinical practice and research, the menstrual cycle phase may not be an important consideration when evaluating plasma volume among women of reproductive age.

【 授权许可】

Unknown