Polyphenols as Potential Agents in the Management of Temporomandibular Disorders

Applied Sciences

Maria Grazia Piancino¹  Ludovica Nucci²  Giuseppe Minervini²  Fabrizia d’Apuzzo²  Carmela Spagnuolo³  Stefania Moccia³ 

[1] Department of Surgical Sciences-Orthodontic division, Dental School, University of Turin, 10124 Turin, Italy;Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania, Luigi Vanvitelli, 80138 Naples, Italy;National Research Council, Institute of Food Sciences, 83100 Avellino, Italy;

关键词: temporomandibular disorders;    temporomandibular joint;    polyphenols;    anti-inflammatory;    osteoarthritis;   

DOI  :  10.3390/app10155305

来源: DOAJ

【 摘 要 】

Temporomandibular disorders (TMD) consist of multifactorial musculoskeletal disorders associated with the muscles of mastication, temporomandibular joint (TMJ), and annexed structures. This clinical condition is characterized by temporomandibular pain, restricted mandibular movement, and TMJ synovial inflammation, resulting in reduced quality of life of affected people. Commonly, TMD management aims to reduce pain and inflammation by using pharmacologic therapies that show efficacy in pain relief but their long-term use is frequently associated with adverse effects. For this reason, the use of natural compounds as an effective alternative to conventional drugs appears extremely interesting. Indeed, polyphenols could represent a potential therapeutic strategy, related to their ability to modulate the inflammatory responses involved in TMD. The present work reviews the mechanisms underlying inflammation-related TMD, highlighting the potential role of polyphenols as a promising approach to develop innovative management of temporomandibular diseases.

【 授权许可】

Unknown