Salvia elegans, Salvia greggii and Salvia officinalis Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes

Molecules

AndreaF. Afonso¹  OlíviaR. Pereira²  ArturM. S. Silva²  SusanaM. Cardoso³  MarceloD. Catarino³ 

[1] LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal;;QOPNA &

关键词: sage;    phenolic compounds;    antioxidant;    α-glucosidase;    pancreatic lipase;    α-amylase;    LC-MS analysis;   

DOI  :  10.3390/molecules23123169

来源: DOAJ

【 摘 要 】

Salvia elegans Vahl., Salvia greggii A. Gray, and Salvia officinalis L. decoctions were investigated for their health-benefit properties, in particular with respect to antioxidant activity and inhibitory ability towards key enzymes with impact in diabetes and obesity (α-glucosidase, α-amylase and pancreatic lipase). Additionally, the phenolic profiles of the three decoctions were determined and correlated with the beneficial properties. The S. elegans decoction was the most promising in regard to the antioxidant effects, namely in the scavenging capacity of the free radicals DPPH^•, NO^• and O₂^•⁻, and the ability to reduce Fe³⁺, as well as the most effective inhibitor of α-glucosidase (EC₅₀ = 36.0 ± 2.7 μg/mL vs. EC₅₀ = 345.3 ± 6.4 μg/mL and 71.2 ± 5.0 μg/mL for S. greggii and S. officinalis, respectively). This superior activity of the S. elegans decoction over those of S. greggii and S. officinalis was, overall, highly correlated with its richness in caffeic acid and derivatives. In turn, the S. officinalis decoction exhibited good inhibitory capacity against xanthine oxidase activity, a fact that could be associated with its high content of flavones, in particular the glycosidic forms of apigenin, scutellarein and luteolin.

【 授权许可】

Unknown