Magnetically Controlled Carbonate Nanocomposite with Ciprofloxacin for Biofilm Eradication

International Journal of Molecular Sciences

Anton Radaev¹  Maria Vishnevskaya¹  Andrey S. Drozdov²  Valeriya Rumyantceva²  Vladimir Vinogradov²  Viktoriya Rumyantceva²  Elena Koshel²  Sofia Tsvetikova²  Yulia Andreeva² 

[1] Chromas Research Resource Center, St. Petersburg State University, 199034 St. Petersburg, Russia;International Institute Solution Chemistry of Advanced Materials and Technologies, ITMO University, Lomonosova st., 9, 191002 St. Petersburg, Russia;

关键词: nanocomposite;    magnetite;    antibiotic;    biofilm;    antimicrobial effect;   

DOI  :  10.3390/ijms22126187

来源: DOAJ

【 摘 要 】

Biofilms are the reason for a vast majority of chronic inflammation cases and most acute inflammation. The treatment of biofilms still is a complicated task due to the low efficiency of drug delivery and high resistivity of the involved bacteria to harmful factors. Here we describe a magnetically controlled nanocomposite with a stimuli-responsive release profile based on calcium carbonate and magnetite with an encapsulated antibiotic (ciprofloxacin) that can be used to solve this problem. The material magnetic properties allowed targeted delivery, accumulation, and penetration of the composite in the biofilm, as well as the rapid triggered release of the entrapped antibiotic. Under the influence of an RF magnetic field with a frequency of 210 kHz, the composite underwent a phase transition from vaterite into calcite and promoted the release of ciprofloxacin. The effectiveness of the composite was tested against formed biofilms of E. coli and S. aureus and showed a 71% reduction in E. coli biofilm biomass and an 85% reduction in S. aureus biofilms. The efficiency of the composite with entrapped ciprofloxacin was higher than for the free antibiotic in the same concentration, up to 72%. The developed composite is a promising material for the treatment of biofilm-associated inflammations.

【 授权许可】

Unknown