Fluid Cartilage as New Autologous Biomaterial in the Treatment of Minor Nose Defects: Clinical and Microscopic Difference Amongst Diced, Crushed, and Fluid Cartilage

Materials

Guy Magalon¹  MariaGiovanni Scioli²  Augusto Orlandi²  Filippo Calcagni³  Alfredo Colaprietra⁴  Aris Sterodimas⁵  Pietro Gentile⁶  Valerio Cervelli⁶  Michele Pascali⁶  Gabriele Toietta⁷  Angelo Trivisonno⁸  StevenR. Cohen⁹  Jèrèmy Magalon^1,10 

[1] Cell Therapy Laboratory, CBT-1409, INSERM, Assistance Publique Hôpitaux de Marseille, 13005 Marseille, France;Department of Biomedicine and Prevention, Tor Vergata University of Rome, 00133 Rome, Italy;Department of Plastic Surgery Catholic University of the Sacred Heart, 00168 Rome, Italy;Department of Plastic Surgery, Campus Bio-Medico University of Rome, 00128 Rome, Italy;Department of Plastic Surgery, IASO General Hospital, Athens 15562, Greece;Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, 00133 Rome, Italy;Department of Research, Advanced Diagnostic, and Technological Innovation, Regina Elena National Cancer Institute, 00144 Rome, Italy;Department of Surgical Science University of Rome “La Sapienza”, 00161 Rome, Italy;FACES+ Plastic Surgery, Skin and Laser Center, La Jolla CA 92121, USA and Division of Plastic Surgery, University of California San Diego, San Diego, CA 92121, USA;Plastic Surgery Department, Assistance Publique Hôpitaux de Marseille (APHM), Aix Marseille University, 13005 Marseille, France;

关键词: fluid cartilage;    minor nose defects;    rhinoplasty;    diced cartilage;    crushing cartilage;   

DOI  :  10.3390/ma12071062

来源: DOAJ

【 摘 要 】

Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Fourteen patients with minor contour deformity were treated with fluid cartilage filler gently injected as autologous fluid graft in deep planes of defect of the nose that were close to the bone or the cartilage. A computerized tomographic scan control was performed after 12 months. Pearson’s Chi-square test was used to investigate differences in cartilage density between native and newly formed cartilages. The endpoints were the possibility of using fluid cartilage as filler with aesthetic and functional improvement and versatility. Patients were followed up for two years. The constructs of fluid cartilage graft that were injected in the deep plane resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation. This report demonstrated that fluid cartilage grafts are useful for cartilage regeneration in patients with outcomes of rhinoplasty, internal nasal valve collapse, and minor congenital nose aesthetics deformity.

【 授权许可】

Unknown