Recent Advances in the Use of Galleria mellonella Model to Study Immune Responses against Human Pathogens

Journal of Fungi

ThaisCristine Pereira¹  LucianaRuano de Oliveira Fugisaki¹  JulianaCampos Junqueira¹  PatríciaPimentel de Barros¹  RodneiDennis Rossoni¹  RaquelTeles de Menezes¹  Felipede Camargo Ribeiro¹  Liliana Scorzoni¹ 

[1] Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, São Paulo 12245-000, Brazil;

关键词: Galleria mellonella;    in vivo study;    experimental model;    hemocytes;    immune response;    melanization;    antimicrobial peptides;    clotting;    free radical production;    primary immunization;   

DOI  :  10.3390/jof4040128

来源: DOAJ

【 摘 要 】

The use of invertebrates for in vivo studies in microbiology is well established in the scientific community. Larvae of Galleria mellonella are a widely used model for studying pathogenesis, the efficacy of new antimicrobial compounds, and immune responses. The immune system of G. mellonella larvae is structurally and functionally similar to the innate immune response of mammals, which makes this model suitable for such studies. In this review, cellular responses (hemocytes activity: phagocytosis, nodulation, and encapsulation) and humoral responses (reactions or soluble molecules released in the hemolymph as antimicrobial peptides, melanization, clotting, free radical production, and primary immunization) are discussed, highlighting the use of G. mellonella as a model of immune response to different human pathogenic microorganisms.

【 授权许可】

Unknown