Matrix Metalloproteases as Influencers of the Cells’ Social Media

International Journal of Molecular Sciences

Daniel Young¹  Anthonia Anowai¹  Antoine Dufour¹  Nabangshu Das² 

[1] Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 4N1, Canada;McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, AB T2N 4N1, Canada;

关键词: matrix metalloproteinases (MMPs);    protease;    inflammation;    signaling;    invasion;    apoptosis;    chemokine;    cytokine;    proteomics;    interferon;   

DOI  :  10.3390/ijms20163847

来源: DOAJ

【 摘 要 】

Matrix metalloproteinases (MMPs) have been studied in the context of cancer due to their ability to increase cell invasion, and were initially thought to facilitate metastasis solely through the degradation of the extracellular matrix (ECM). MMPs have also been investigated in the context of their ECM remodeling activity in several acute and chronic inflammatory diseases. However, after several MMP inhibitors failed in phase III clinical trials, a global reassessment of their biological functions was undertaken, which has revealed multiple unanticipated functions including the processing of chemokines, cytokines, and cell surface receptors. Despite what their name suggests, the matrix aspect of MMPs could contribute to a lesser part of their physiological functions in inflammatory diseases, as originally anticipated. Here, we present examples of MMP substrates implicated in cell signaling, independent of their ECM functions, and discuss the impact for the use of MMP inhibitors.

【 授权许可】

Unknown