Mechanical and biological evaluation of lattice structured hydroxyapatite scaffolds produced via stereolithography additive manufacturing

Materials & Design

Sang-Won Park¹  Jin-Ho Kang²  Kumaresan Sakthiabirami²  Chan Park²  Kyoung-Jun Jang²  Jae-Gon Jang²  Gye-Jeong Oh³  John G. Fisher⁴ 

[1] Engineering, Chonnam National University, Gwangju 61186, Republic of Korea;Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea;RIS Foundation for Advanced Biomaterials, School of Dentistry, Chonnam National University, Gwangju 61186, Republic of Korea;;School of Materials Science &

关键词: Additive manufacturing;    Stereolithography apparatus;    Photopolymerization suspension;    Hydroxyapatite;    Octahedral structure;   

DOI  :  

来源: DOAJ

【 摘 要 】

A photocurable hydroxyapatite (HA) suspensions were prepared and optimized to construct three-dimensional (3D) scaffolds with lattice structures for application in bone tissue engineering. The HA suspensions were categorized into five groups based on the HA contents (designated as HA 30, 32.5, 35, 37.5, and 40 (vol%)). This study demonstrated the applicability of the optimized HA suspension for manufacturing scaffolds using a commercially available stereolithography apparatus (SLA). Disk samples prepared with the HA 35 suspension exhibited the highest bending strength and relative density. Cell attachment experiments revealed that the sintered HA disks did not exhibit cytotoxicity. Furthermore, various types of scaffolds (octahedral, circular, and frame) were designed and constructed using the optimal HA suspension. The designed octahedral scaffold exhibited the highest compressive strength, achieved a break strength improvement of 245% compared with the circular scaffolds, and showed significant differences from the other scaffold types in bone cell proliferation and differentiation experiments. The ceramic suspension formulation proposed herein can be commonly applied for all commercialized 3D SLAs. Furthermore, the use of the octahedral scaffold effectively overcomes the strength issues associated with the ceramic product. This study would aid future research on scaffolds containing various biomaterials and designs prepared using additive manufacturing technology.

【 授权许可】

Unknown