Acta Médica Portuguesa | |
Analysis of the Cochrane Review: Topical Treatments for Scalp Psoriasis. Cochrane Database Syst Rev. 2016;2:CD009687. | |
António Vaz-Carneiro1  João Costa2  Gonçalo Silva Duarte2  Catarina Soares Queirós3  | |
[1] Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.Centro Colaborador Português da Rede Cochrane Iberoamericana. Lisboa. Portugal.;Laboratório de Farmacologia Clínica e Terapêutica. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.Clinical Pharmacology Unit. Instituto de Medicina Molecular. Lisboa. Portugal.Centro de Estudos de Medicina Baseada na Evidência. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.;Serviço de Dermatologia. Hospital de Santa Maria. Lisboa. Portugal.; | |
关键词: Administração Tópica; Dermatoses do Couro Cabeludo/tratamento; Esteroides; Fármacos Dermatológicos/uso terapêutico; Psoriase/tratamento; Revisão Sistemática; Vitamina D; | |
DOI : 10.20344/amp.8910 | |
来源: DOAJ |
【 摘 要 】
Regardless the psoriasis subtype, up to 79% of people with this skin condition present scalp involvement, which is often the first site to show symptoms of the disease. In addition to being itchy, the red and scaly lesions are usually easy to see, and may be embarrassing. Topical therapy is usually the first line of treatment; however the wide array of available interventions can make the choice difficult, and may even lead to an inadequate treatment. The objective of this review was to evaluate the efficacy and safety of topical treatments for scalp psoriasis. A systematic review was performed according to the methodology recommended by Cochrane in order to evaluate the clinical severity of psoriasis, quality of life, and adverse events that led to treatment discontinuation. To evaluate this, 59 studies were included, with a total of 11 561 participants, and 15 comparisons were made between the various drugs and application vehicles tested. The principal conclusion is that corticosteroids of high or very high potency are more effective than vitamin D. The combination of a corticosteroid with vitamin D has only a marginal benefit over corticosteroid monotherapy, but is superior to vitamin D alone. Given the similar safety profile and only marginal benefit of the combination of corticosteroid with vitamin D over the corticosteroid alone, topical corticosteroid monotherapy appears to be fully acceptable for short-term therapy of scalp psoriasis.
【 授权许可】
Unknown