New insights on atherosclerosis: A cross-talk between endocannabinoid systems with gut microbiota

Journal of Cardiovascular and Thoracic Research

Mohammad Alizadeh¹  Ned Lotfi Yagin¹  Jalal Moludi¹  Yahiya Pasdar²  Seyed Mostafa Nachvak²  Hadi Abdollahzad²  Ali Sadeghpour Tabaei³ 

[1] Nutrition Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran;Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran;Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran;

关键词: atherosclerosis;    endocannabinoids;    gastrointestinal microbiome;    probiotics;    trimethylamine-n-oxide;   

DOI  :  10.15171/jcvtr.2018.21

来源: DOAJ

【 摘 要 】

The incidence of atherosclerosis is increasing rapidly all over the world. Inflammatory processes have outstanding role in coronary artery disease (CAD) etiology and other atherosclerosis manifestations. Recently attentions have been increased about gut microbiota in many fields of medicine especially in inflammatory diseases like atherosclerosis. Ineffectiveness in gut barrier functions and subsequent metabolic endotoxemia (caused by rise in plasma lipopolysaccharide levels) is associated with low-grade chronic inflammation i.e. a recognized feature of atherosclerosis. Furthermore, the role of trimethylamine-N-oxide (TMAO), a gut bacterial metabolite has been suggested in atherosclerosis development. On the other hand, the effectiveness of gut microbiota modulation that results in TMAO reduction has been investigated. Moreover, considerable evidence supports a role for the endocannabinoid system (ECS) in atherosclerosis pathology which affects gut microbiota, but their effects on atherosclerosis are controversial. Therefore, we presented some evidence about the relationship between gut microbiota and ECS in atherosclerosis. We also presented evidences that gut microbiota modulation by pre/probiotics can have significant influence on the ECS.

【 授权许可】

Unknown