Imaging-derived Biomarkers Associated with Atrial FIBROsis, Structural Remodeling and the Risk of Cardioembolic Events in Patients with Atrial Fibrillation – the FIBROS Study

Journal of Interdisciplinary Medicine

Oltean-Péter Balázs¹  Korodi Szilamér¹  Lázár Erzsébet¹  Mitre Adriana¹  Pakucs Annamária¹  Benedek István¹  Benedek Imre¹  Kéri Johanna¹  Kovács István¹  Bordi Lehel¹  Benedek Theodora¹ 

[1] University of Medicine and Pharmacy, Tîrgu Mureș, Romania;

关键词: atrial fibrillation;    atrial fibrosis;    inflammation;    coagulation;    stroke;    thrombosis;    magnetic resonance;    ablation;   

DOI  :  10.1515/jim-2017-0095

来源: DOAJ

【 摘 要 】

Recent studies demonstrated that despite restoration of the sinus rhythm, patients with a positive history of atrial fibrillation (AF) are still at risk of thromboembolic events. The primary objective of this study is to identify new imaging-derived biomarkers provided by modern imaging technologies, such as cardiac computed tomography angiography, delayed enhancement magnetic resonance imaging, or speckle tracking echocardiography, as well as hematological biomarkers, associated with the risk of intracavitary thrombosis in patients with AF, in order to identify the imaging-derived characteristics associated with an increased risk of cardioembolic events. Imaging data collected will be post-processed using advanced techniques of computational modeling, in order to fully characterize the degree of structural remodeling and the amount of atrial fibrosis. The primary endpoint of the study is represented by the rate of thromboembolic events. The rate of cardiovascular death, the rate of major adverse cardiovascular events, and the rate of AF recurrence will also be determined in relation to the degree of structural remodeling and atrial fibrosis.

【 授权许可】

Unknown