Sex Differences in Characteristics of Patients with Infective Endocarditis: A Multicenter Study

Journal of Clinical Medicine

Aravinda Nanjundappa¹  Mark Bates¹  Shabnam Tiwari²  Ruchi Bhandari²  Gordon S. Smith²  Talia Alexander²  Frank H. Annie³  Ellen Thompson⁴  Umar Kaleem⁴  Affan Irfan⁴  R. Constance Wiener⁵  Chris Cook⁶  Melanie A. Fisher⁶  Sudarshan Balla⁶  Judith Feinberg⁶ 

[1] Department of Cardiovascular Medicine, Charleston Area Medical Center, Charleston, WV 25304, USA;Department of Epidemiology and Biostatistics, School of Public Health, West Virginia University, Robert C Byrd Health Sciences Center North, 64 Medical Center Drive, Morgantown, WV 26506, USA;Health Education and Research Institute, Charleston Area Medical Center, Charleston, WV 25304, USA;Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA;School of Dentistry, West Virginia University, Morgantown, WV 26506, USA;School of Medicine, West Virginia University, Morgantown, WV 26506, USA;

关键词: infective endocarditis;    West Virginia;    sex;    male-female differences;    electronic medical records;   

DOI  :  10.3390/jcm11123514

来源: DOAJ

【 摘 要 】

Infectious diseases like infective endocarditis (IE) may manifest or progress differently between sexes. This study sought to identify the differences in demographic and clinical characteristics among male and female patients with IE. Data were obtained from a newly developed registry comprising all adult patients with first IE admission at the four major tertiary cardiovascular centers in West Virginia, USA during 2014–2018. Patient characteristics were compared between males and females using Chi-square test, Fisher’s exact test, and Wilcoxon rank-sum test. A secondary analysis was restricted to IE patients with drug use only. Among 780 unique patients (390 males, 390 females), significantly more women (a) were younger than males (median age 34.9 vs. 41.4, p < 0.001); (b) reported drug use (77.7% vs. 64.1%, p < 0.001); (c) had tricuspid valve endocarditis (46.4% vs. 30.8%, p < 0.001); and (d) were discharged against medical advice (20% vs. 9.5%, p < 0.001). These differences persisted even within the subgroup of patients with drug use-associated IE. In a state with one of the highest incidences of drug use and overdose deaths, the significantly higher incident IE cases in younger women and higher proportion of women leaving treatment against medical advice are striking. Differential characteristics between male and female patients are important to inform strategies for specialized treatment and care.

【 授权许可】

Unknown