Auxiliary diagnostic potential of ventricle geometry and late gadolinium enhancement in left ventricular non-compaction; non-randomized case control study

BMC Cardiovascular Disorders

Ivo Darko Gabric¹  Sime Manola¹  Viktor Persic²  Vladimir Pesa²  Helena Antic-Kauzlaric²  Marko Boban²  Aleksandar Vcev³  Marinko Zulj³ 

[1] Department of Cardiology, University Hospital “Sestre Milosrdnice” Zagreb;Department of Cardiology, University hospital “Thalassotherapia Opatija”, Faculty of Medicine, University of Rijeka;Department of Internal medicine, Faculty of Medicine, “J.J. Strossmayer” University of Osijek;

关键词: Left ventricle non-compaction (LVNC);    Late gadolinium enhancement (LGE);    Cardiac magnetic resonance imaging (CMR);    Left ventricular geometry;   

DOI  :  10.1186/s12872-017-0721-0

来源: DOAJ

【 摘 要 】

Abstract Background There are still ambiguities existing in regard to left ventricular non-compaction (LVNC) diagnostic imaging. The aim of our study was to analyze diagnostic potential of late gadolinium enhancement (LGE) and ventricle geometry in patients with LVNC and controls. Methods Data on cardiac magnetic resonance imaging (CMR) studies for LVNC were reassessed from the hospital’s database (3.75 years; n=1975 exams). Matching sample of controls included cases with no structural heart disease, hypertrophic or dilative cardiomyopathy, arrhythmogenic right ventricular dysplasia or subacute myocarditis. Eccentricity of the left ventricle was measured at end diastole in the region with pronounced NC and maximal to minimal ratio (MaxMinEDDR) was calculated. Results Study included 255 patients referred for CMR, 100 (39.2%) with LVNC (prevalence in the studied period 5.01%) and 155 (60.8%) controls. Existing LGE had sensitivity of 52.5% (95%-CI:42.3–62.5), specificity of 80.4% (95%-CI:73.2–86.5) for LVNC, area under curve (AUC) 0.664 (95%-CI:0.603–0.722);p<0.001. MaxMinEDDR>1.10 had sensitivity of 95.0% (95%-CI:88.7–98.4), specificity of 82.6% (95%-CI: 75.7–88.2) for LVNC, AUC 0.917 (95%-CI:0.876–0.948); p<0.001. LGE correlated with Max-Min-EDD-R (Rho=0.130; p=0.038) and there was significant difference in ROC analysis ΔAUC0.244 (95%-CI:0.175–0.314); p<0.001. LGE also correlated negatively with stroke volume and systolic function (both p<0.05, respectively). Conclusions LGE was found to be frequently expressed in patients with LVNC, but without sufficient power to be used as a discriminative diagnostic parameter. Both LGE and eccentricity of the left ventricle were found to be relatively solid diagnostic landmarks of complex infrastructural and functional changes within the failing heart.

【 授权许可】

Unknown