Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

Plants

Yuthana Phimolsiripol¹  Pornchai Rachtanapun¹  Kittisak Jantanasakulwong¹  Sarana Rose Sommano²  Korawan Sringarm²  Francisco David Carmona³  Chaiwat Arjin⁴  Chiranan Khantham⁵  Chuda Chittasupho⁵  Warintorn Ruksiriwanich⁵  Pichchapa Linsaenkart⁵  Pensak Jantrawut⁵  Tanakarn Chaitep⁵  Wutigri Nimlamool⁶  Francisco J. Barba⁷  Houda Berrada⁷  Sansanee Jamjod⁸  Chanakan Prom-u-thai⁸ 

[1] Cluster of Agro Bio-Circular-Green Industry, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand;Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, Thailand;Departamento de Genética e Instituto de Biotecnología, Universidad de Granada, 18071 Granada, Spain;Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand;Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand;Department of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de València, 46100 València, Spain;Lanna Rice Research Center, Chiang Mai University, Chiang Mai 50200, Thailand;

关键词: androgenetic alopecia;    anti-hair loss;    anti-inflammation;    bioactive compounds;    Oryza sativa;    5α-reductase gene expression;   

DOI  :  10.3390/plants11030330

来源: DOAJ

【 摘 要 】

Androgenetic alopecia (AGA), a hair loss disorder, is a genetic predisposition to sensitive androgens, inflammation, and oxidative stress. Unfortunately, current treatments with synthetic medicines contain a restricted mechanism along with side effects, whereas the bioactive constituents of plant extracts are multifunctional, with fewer side effects. The massive amounts of rice husk and bran are agricultural wastes that may cause pollution and environmental problems. Owing to these rationales, the local rice variety, Bue Bang 3 CMU (BB3CMU), which is grown in northern Thailand, was evaluated for the valuable utilization of rice by-products, husk (BB3CMU-H) and bran (BB3CMU-RB) extracts, for AGA treatment regarding antioxidant, anti-inflammatory, anti-androgenic activities, and the characterization of bioactive compounds. Our study verified that BB3CMU-H had the highest level of polyphenols, contributing to its greater antioxidant activity. Conversely, BB3CMU-RB was the predominant source of tocopherols, resulting in better anti-androgenic activities regarding the downregulation of steroid 5α-reductase genes (SRD5A). Notably, anti-inflammation via the attenuation of nitric oxide productions was observed in BB3CMU-H (0.06 ± 0.13 μM) and BB3CMU-RB (0.13 ± 0.01 μM), which were significantly comparable to diclofenac sodium salt (0.13 ± 0.19 μM). Therefore, the combination of BB3CMU-H and BB3CMU-RB could be utilized in cosmeceutical and pharmaceutical applications for AGA patients.

【 授权许可】

Unknown