Caspase-9和Survivin在肝癌组织中的表达及意义

Linchuang Gandanbing Zazhi

GUO Xiaodong¹ 

[1] 302 Hospital of PLA;

关键词: carcinoma;    hepatocellular;    caspase 9;    inhibitor of apoptosis proteins;    immunohistochemistry;   

DOI  :  10.3969/j.issn.1001-5256.2014.03.014

来源: DOAJ

【 摘 要 】

ObjectiveTo investigate the expression of Caspase-9 and Survivin in hepatocellular carcinoma (HCC) tissues and its clinical significance. MethodsThe immunohistochemical SP method was used to measure the expression of Caspase-9 and Survivin in the HCC tissues and paracancerous normal liver tissues of 92 HCC patients, and the relationship between their expression and the clinical malignant biological behavior of HCC was analyzed. ResultsCompared with paracancerous normal liver tissues, the HCC tissues had significantly lower expression of Caspase-9 (χ2=6.48, P<0.05) and significantly higher expression of Survivin (χ2=7.05, P<0.05). The positive rate of Survivin in HCC tissues was significantly higher in patients with TNM stage III-IV disease, with portal vein tumor thrombus (PVTT), and with lymph node metastasis (LNM) than in those with TNM stage I-II disease, without PVTT, and without LNM (χ2=507, P<0.05; χ2=6.18, P<0.05; χ2=8.29, P<0.05), but no significant differences were found between other group pairs. The positive rate of Caspase-9 in HCC tissues was significantly lower in patients with pathological stage III-IV disease than in those with pathological stage I-II disease (χ2=7.63, P<0.05), but no significant differences were found between other group pairs. ConclusionLow expression of Caspase-9 and abnormally high expression of Survivin were both involved in the development of HCC. Low expression of Caspase-9 may be closely associated with the malignant differentiation of HCC cells, and high expression of Survivin is closely associated with the malignant progression, such as invasion and distant metastasis, of HCC.

【 授权许可】

Unknown