Sending out an SOS: Mitochondria as a signaling hub

Frontiers in Cell and Developmental Biology

Oleh Khalimonchuk¹  Iryna Bohovych¹ 

[1] University of Nebraska-Lincoln;

关键词: Mitochondria;    Reactive Oxygen Species;    Metabolites;    Mitochondrial stress;    retrograde signaling;   

DOI  :  10.3389/fcell.2016.00109

来源: DOAJ

【 摘 要 】

Normal cellular physiology is critically dependent on numerous mitochondrial activities including energy conversion, cofactor and precursor metabolite synthesis, and regulation of ion and redox homeostasis. Advances in mitochondrial research during the last two decades provides solid evidence that these organelles are deeply integrated with the rest of the cell and multiple mechanisms are in place to monitor and communicate functional states of mitochondria. In many cases, however, the exact molecular nature of various mitochondria-to-cell communication pathways is only beginning to emerge.Here, we review various signals emitted by distressed or dysfunctional mitochondria and the stress-responsive pathways activated in response to these signals in order to restore mitochondrial function and promote cellular survival.

【 授权许可】

Unknown