Fatal hemothorax caused by pleural mesothelioma in a lion

Pesquisa Veterinária Brasileira

关键词: Hemotórax;    imuno-histoquímica;    Panthera leo;    leão;    mesotelioma pleural;    animais de zoológico;    animais silvestres;    patologia;   

DOI  :  10.1590/1678-5150-pvb-6184

来源: DOAJ

【 摘 要 】

ABSTRACT: Mesothelioma is considered a malignant neoplasm caused by the proliferation of mesothelial cells mostly from the pleura, peritoneum and pericardium. Here we described a case of fatal hemothorax caused by pleural mesothelioma in a lion by means of necropsy, histopathology and immunohistochemistry. Gross inspection of the thoracic cavity showed hemothorax with about 4 liters of blood. Microscopically, numerous, randomly distributed, soft, red-pink, irregular masses with up to 1cm in diameter were observed in both visceral and parietal pleurae. Microscopically, a papillary structure pattern was observed in the thoracic masses, composed mainly by one layer of cubic mesothelial cells, which presented eosinophilic cytoplasm, central nucleus and evident nucleolus, supported by a low cellular fibrovascularstroma. Neoplastic cells were positive for both cytokeratin and vimentin by immunohistochemistry. This seems to be the first report of fatal hemothorax caused by pleural mesothelioma in a lion.

【 授权许可】

Unknown