Overview on Molecular Biomarkers for Laryngeal Cancer: Looking for New Answers to an Old Problem

Cancers

Annalisa Itro¹  Carlo Irace²  Angela Lombardi³  Chiara Tammaro³  Giuseppe Scafuro³  Takashi Takeuchi³  Alessia Maria Cossu³  Michela Falco³  Silvia Zappavigna³  Michele Caraglia³  Gabriella Misso³  Filippo Ricciardiello⁴  Marianna Scrima⁵  Raffaele Addeo⁶ 

[1] Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy;Department of Pharmacy, School of Medicine and Surgery, University of Naples “Federico II”, 80131 Naples, Italy;Department of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy;Division of Otorhinolaryngology, “A. Cardarelli” Hospital, 80131 Naples, Italy;Laboratory of Molecular and Precision Oncology, Biogem Scarl, Institute of Genetic Research, 83031 Ariano Irpino, Italy;Oncology Operative Unit, Hospital of Frattamaggiore, ASLNA-2NORD, 80020 Naples, Italy;

关键词: LSCC (laryngeal squamous cell carcinoma);    miRNA;    lncRNA;    biomarkers;    epigenetic modifications;    ctDNA;   

DOI  :  10.3390/cancers14071716

来源: DOAJ

【 摘 要 】

Laryngeal squamous cell cancer (LSCC) accounts for almost 25–30% of all head and neck squamous cell cancers and is clustered according to the affected districts, as this determines distinct tendency to recur and metastasize. A major role for numerous genetic alterations in driving the onset and progression of this neoplasm is emerging. However, major efforts are still required for the identification of molecular markers useful for both early diagnosis and prognostic definition of LSCC that is still characterized by significant morbidity and mortality. Non-coding RNAs appear the most promising as they circulate in all the biological fluids allowing liquid biopsy determination, as well as due to their quick and characteristic modulation useful for non-invasive detection and monitoring of cancer. Other critical aspects are related to recent progress in circulating tumor cells and DNA detection, in metastatic status and chemo-refractoriness prediction, and in the functional interaction of LSCC with chronic inflammation and innate immunity. We review all these aspects taking into account the progress of the technologies in the field of next generation sequencing.

【 授权许可】

Unknown