Triphenyl phosphate exposure induces kidney structural damage and gut microbiota disorders in mice under different diets

Environment International

Mei Li¹  Yeqian Chang²  Xiaofeng Jiang²  Haiyan Cui² 

[1] Corresponding author at: 163 Xianlin Ave., Nanjing University, Nanjing 210023, China.;State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, China;

关键词: Triphenyl phosphate;    Kidney structural damage;    Gut microbiota;    High fructose and fat;    16S rRNA sequencing;   

DOI  :  

来源: DOAJ

【 摘 要 】

Exposure of humans to organophosphate flame retardants (OPFRs) and the consequent health risk have increased owing to the latter’s widespread application. Although triphenyl phosphate (TPP), an OPFR, is a potential chemical determinant of liver function damage, its effects on kidney function in mice under high fructose/fat (HFF) diet are still unclear. In this study, C57BL/6J mice were fed HFF to generate an obesity model and mice were exposed to low dose (0.01 mg/kg/day; TPP-L) and high dose (1 mg/kg/day; TPP-H) of TPP for 12 weeks. Results showed that TPP-L and TPP-H combined with HFF, as well as TPP-H alone, caused kidney structural damage and gut microbiota disorders in mice. Inflammatory response induced by nuclear factor kappa B (NF-κB p65)/nod-like receptor protein 3 (NLRP3) and caspase-3 promoted kidney structure damage, as well as accumulation of triglyceride and total cholesterol and the protein residues in urine. Although TPP-L did not cause obvious structural damage in the kidneys, 0.01 mg/kg TPP induced significant inflammation and gut microbiota disorders. These findings provide new insights regarding health risk assessment after chronic exposure to TPP and HFF alone, as well as a combination of TPP with HFF in mice.

【 授权许可】

Unknown